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April 2016

Volume 3 Issue 1


Research article

Three-Dimensional Conformal Radiotherapy Combined Transcatheter Arterial Chemoembolization for Patients with Hepatocellular Carcinoma with Tumor Thrombus

Tomoharu Akai*, Satoshi Nomoto, Shinichi Koura, Hiroshi Urakawa, Toshimichi Mitsufuji, Akinobu Osame, Yasuo Kuwabara, Kengo Yoshimitsu

The purpose of this study was to evaluate the outcomes of three-dimensional conformal radiation therapy (3D-CRT) combined with transcatheter arterial chemoembolization (TACE) for portal vein tumor thrombus (PVTT) and/or inferior vena cava tumor thrombus (IVCTT) in patients with hepatocellular carcinoma (HCC). Thirteen patients with HCC and PVTT and/ or IVCTT were treated with this combined treatment modality from 2009 to 2013. TACE was performed for the intrahepatic main body of HCC, PVTT and/or IVCTT via selective feeding arteries using lipiodol, cisplatin or epirubicin hydrochloride, followed by gelatin sponge particles.


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Short Communication

Impact of HIV Status and Protease Inhibitor Use on Blood Counts during Chemotherapy and Radiation Treatment for Anal and Lung Cancers

Raima M. Amin, Kaitlynn M. Ebisutani, Jing Zeng*

Aggressive cancer treatment for patients with HIV on HAART therapy can achieve similar outcomes to cancer patients without HIV. However, HIV protease inhibitors, often used in HIV treatment, are radiation sensitizers and have been tested in clinical trials to improve the efficacy of treatment. Here, we explore whether HIV status and the use of protease inhibitors during chemoradiation has an impact on blood counts during treatment for anal cancer and lung cancer.


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Review Article

Gold Nanoparticles for Radiation Enhancement in Vivo

Samana Shrestha, Leon N Cooper, Oleg A. Andreev, Yana K. Reshetnyak and Michael P. Antosh*

Enhancing the effect of radiation on tumors would be a significant improvement in radiation therapy. With radiation enhancement, less radiation could be used to achieve the same goals, lessening damage to healthy tissue and lessening side effects. Gold nanoparticles are a promising method for achieving this enhancement, particularly when the gold nanoparticles are targeted to cancer. This literature review discusses the properties of gold nanoparticles as well as existing in vivo radiation enhancement results using both targeted and non-targeted gold nanoparticles.


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