Volume 1 Issue 2
The Potential Roles of Radiation-Induced Bystander Effects in Radiation Therapy
Radiation-induced bystander effects (RIBEs) refer to the biological changes in unirradiated cells or tissues when the neighboring cells or tissues are traversed by ionizing radiation, such as changes in gene expression, DNA damage, cell killing, malignant transformation, epigenetic alterations et al.
Using a Robotic Stereotactic Radiation Treatment System for Re-Irradiation may be Safe and Effective
Rex Cheung*, MD, PhD, Josephine Kang, MD, PhD, and Vincent Yeung, MD
With the advent of systematic treatment cancer patients are living longer. This has led to an increase in the number of local recurrences facing radiation oncologists. Among the salvage treatment strategies, re-irradiation has been used successfully in addition to salvage chemotherapy and surgery.
Clinical Research Article
Prognostic Analysis in Patients with Metastatic Nasopharyngeal Carcinoma at Initial Diagnosis
Chengtao Wang M.D, Ph.D, Peiyu Huang M.D, Ph.D, Ling Guo M.D, Ph.D, Zhenyu Wang Ph.D, Tian Zhang M.D, Ph.D, Jun Dong M.D, Ph.D, Junli Shi M.D, Ph.D, Yin Li M.D, Ph.D, Xiang Guo M.D, Ph.D, Kajia Cao M.D, Ph.D*, Bixiu Wen M.D, Ph.D*
The aim of this study was to investigate the prognostic factors and to provide a data foundation for the therapeutic decision in patients with metastatic nasopharyngeal carcinoma (NPC) at initial diagnosis. We did a retrospective study to explore 256 NPC patients with distant metastases at initial diagnosis (M1 stage) between January 1997 and December 2004. Univariate and multivariate analyses showed that gender, N staging, and treatment modality were independent prognostic factors for M1 stage NPC patients. Patients who received comprehensive treatment showed favorable prognosis, and some could achieve long-term survival.
Pseudo-abscess Formation in a 55 Year Old Female with HPV Positive Tonsillar Squamous Cell Carcinoma: A Case Report
Jameson T. Mendel, MS-IV and Sun K. Yi*, MD
Cystic nodal degeneration is known to be associated with HPV positive squamous cell carcinoma (SCC) of the head and neck. Differentiating between abscess formation and cystic degeneration is critical although often difficult to determine clinically. We present a case of a patient with very locally advanced HPV positive tonsillar SCC with rapidly expanding neck mass of unclear etiology. Herein we describe the potential utilization of diffusion weighted MRI for narrowing the diagnosis.
Morbidity Associated with False-Positive Findings in Post-Treatment Positron Emission Tomography/Computed Tomography in Chemoradiation Treated Head and Neck Cancer Patients
Sun K. Yi*, M.D., Sarah Kratz, M.D., TJ Gernon, M.D., Audrey Erman, M.D., Rihan Khan, M.D., Ryan Avery, M.D., Fatima Aly, M.D., Phillip H. Kuo, M.D., Ph.D., Michael K. Cheung, M.D., Georgi Georgiev, M.S.
Positron emission tomography/computed tomography (PET/CT) for chemoradiation treated Head and Neck (HN) cancer is often utilized for post-treatment surveillance. Early detection of persistent or recurrent disease may allow for surgical salvage, however false positive or ambiguous findings on initial PET/CT surveillance may lead to premature invasive intervention and associated morbidity. We present a case of a 58 year old male treated definitively with chemoradiation for locally advanced HN squamous cell carcinoma (SCC) who presented with ambiguous initial 90 day post treatment PET/CT, leading to biopsy and subsequent progressive radionecrosis and superinfection.
Clinical and Radiologic Toxicity after Thoracic Stereotactic Body Radiation Therapy
Priya Mitra*, M.D., David Randolph, M.D., Mark Parker, M.D., Patricia DeGroot, M.D., Nitai Mukhopadhyay, Ph.D, Elisabeth Weiss, M.D
Knowledge about treatment-related toxicity of stereotactic body radiotherapy to the lung is still limited. We conducted a retrospective review of patients treated with stereotactic radiotherapy at our institution to determine the incidence of clinical and radiologic toxicity and their correlation with dosimetric parameters.