Volume 3 Issue 3
Carbon ions Versus γ-Irradiation: The Telomeric Effect in Cancer Cells
Sylvain Ferrandon (PhD), Badia El Hamdani (MD)., Sophie Gazzo (MD), Priscilla Batiston-Montagne (Tech), Michael Beuve (Pr.), Claire Rodriguez-Lafrasse (Pr.), Delphine Poncet (PharmD. PhD.)*
Carbon ions (C+) hadrontherapy is an alternative treatment for radio-resistant tumors. Compared with photon irradiation (γ -IR), C+ has demonstrated a higher Relative Biological Efficiency (RBE) in vitro and in vivo. Clustered DNA lesions called Locally Multiply Damaged Sites (LMDS) are more difficult to repair and are therefore responsible for the higher RBE of C+ irradiation. In contrast, isolated double strand breaks (DSBs) are thought to be the primary determinant of cell death after γ -IR with a minor implication for LMDS. However, the genomic region damaged by these types of irradiation can also influence the RBE. Telomeres, the heterochromatin structure located at the end of chromosomes, play different roles in response to C+ and γ-IR.
Radiotherapy and Rosai-Dorfman Disease
Antonio Cássio Assis Pellizzon*, MD, Ph.D., Ricardo Cesar Fogaroli, MD, Maria Leticia Gobo Silva, MD, Michael Jenwei Chen, MD, Guilherme Gondim, MD, Douglas de Castro Guedes, MD, Henderson Ramos, MD
Rosai–Dorfman disease (RDD) also known as histiocytosis with lymphadenopathy is uncommon, often self-limiting benign, not–Langerhans-cell histiocytic proliferative disorder. It usually affects young adults and children, with no predilection for sex. More than 80% of patients present with painless cervical lymphadenopathy, with or without fever. Other presentation sites include upper aero-digestive tract, orbits, and the paranasal sinuses. Extra nodal involvement can occur from 20% to more than 40% of cases, and common sites of involvement include the skin, upper airway, soft tissue, bones kidney, lower respiratory tract, liver, orbit and central nervous system.
Database Verification Using Cryptographic Secure Hash Algorithm following Eclipse/Aria Version Upgrade and Database Migration
Zhigang Xu*, Jamie Todd Baker and Samuel Ryu
Software upgrades of Aria Electronic Medical Record (EMR) and Eclipse Treatment Planning System (TPS) require that all data be migrated from one version of the database to another. It is necessary to verify that the data is correctly migrated to assure patient safety. Traditionally Quality Assurance (QA) checks of a patient’s radiation therapy plan and dose information involve printing out treatment parameters of each patient from the Eclipse TPS and Aria EMR system and visually checking the information for one-to-one correspondence.