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September  2014

Volume 1 Issue 1
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Editorial

A Practical Solution to Socioeconomic Barriers to Radiotherapy in New York City
Rex Cheung MD*, PhD, Daniel Ouyang MD, MS, Josephine Kang, MD, PhD, Helen Li, MD, PhD, Vincent Yeung, MD.

Surveillance Epidemiology and End Results (SEER) is a public use cancer registry of United States of America (US). SEER is funded by National Cancer Institute and Center for Disease Control. It covers 28% of all oncology cases in US.                                                                                                                                                                                                                                                             Full textDownload PDF      
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Case Report

Limited Stage Small Cell Carcinoma of the Anal Canal: A Case Report and Review of the Literature
Melvin Deutsch*  and John A Vargo , Mohammed Islam and Sherif Rizk

Extrapulmonary small cell carcinoma is a rare disease entity of epithelial origin accounting for less than 0.2% of all colorectal malignancies. Here-in we describe a case report of a patient with small cell carcinoma of the anal canal treated with concurrent platinum-etoposide based chemoradiotherapy followed by prophylactic cranial irradiation.                                                                                                                                                                                                                                                     Full textDownload PDF      ___________________________________________________________________________________________

 Editorial

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells

Haibo Wang, Sanjay Adhikari, Brian E. Butler, Tej K. Pandita, Sankar Mitra, and Muralidhar L. Hegde*

The DNA damage response (DDR) in mammalian cells is a complex and highly orchestrated signaling process that regulates the recruitment of specific DDR proteins to the DNA damage sites. The most lethal type of DNA damage is the double-strand break (DSB), which is generated by ionizing radiation (IR), radiomimetic drugs and also drugs of DNA topoisomerase 2 poison family. DSBs are also endogenously caused during replication of single-strand breaks generated by reactive oxygen species or at stalled replication forks.                                                                                                                                                                                                                                                   Full textDownload PDF

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Research Article

A Closer Look at Extraprostatic Extension: Evaluation of PSA Relapse Rates Following Prostatectomy for pT3aN0 Prostate Cancer with or without Margin Involvement

John M. Watkins*, Michael Laszewski, Mark Rodacker, Patricia L. Watkins, Tarek A. Dufan, Nadim Koleilat, ChristopherAdducci

Introduction: Extraprostatic extension (EPE) is an established risk factor for recurrence following radical prostatectomy (RP); for pT3aN0 patients with EPE who were followed without adjuvant therapy. however, often this is identified in the context of other high-risk features. 

 

                                                                                                                                                                                                                                   Full textDownload PDF

 

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Research Article

Anatomy Based Patient Specific IMRT QA Using EPID or MLC Log Files

Dewayne Defoor, Luis A Vazquez Quino , Panayiotis Mavroidis, Niko Papanikolaou, Sotirios Stathakis*

In this project, we investigated the use of an Electronic portal imaging device (EPID), together with the treatment planning system (TPS), in order to determine the delivered doses to the patient and evaluate the agreement between the treatment plan and the delivered dose distribution.         

                                                                                                                                                                                                                        Full textDownload PDF

 

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Research Article

Interobserver and Intermodality Variability in GTV Delineation on Simulation CT,FDG- PET, and MR Images of Head and Neck Cancer

Carryn M. Anderson*, Wenqing Sun, John M. Buatti, Joan E. Maley, Bruno Policeni, Sarah L. Mott, John E. Bayouth

To compare the interobserver and intermodality differences in image-based identification of head and neck primary site gross tumor volumes (GTV). Modalities compared include: contrast-enhanced CT, F-18 fluorodeoxyglucose positron emission tomography (PET/CT) and contrast-enhanced MRI.         

                                                                                                                                                                                                                                   Full textDownload PDF

 

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Short Commentary

Using Stereotactic Radiation Systems to Irradiate and Re-Irradiate Head and Neck Cancers

Rex Cheung*, MD, PhD

Head and neck cancers are challenging to treat with conventional radiation therapy. There are many critical structures that include optic chiasm, optic nerves, cochlea, eyes, temporal lobes, brain stem, spinal cord, parotid glands, mandible, esophagus and larynx. Among the head and neck cancers, nasopharyngeal cancers, skull base cancers, and recurrent head and neck cancers are the most challenging to irradiate.

                                                                                                                                                                                                                                                    Full textDownload PDF


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