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September 2015

Volume 2 Issue 3


Clinical Research Article

Patterns of Recurrence in Malignant Glioma Patients: Association with Subventricular Zone and Radiotherapy Dose

Hiroshi Igaki, M.D., Ph.D.,* Taiki Magome, Ph.D., Madoka Sakuramachi, M.D., Akihiro Nomoto, M.D., Akira Sakumi, Ph.D., Mayuka Kitaguchi, M.D., Akihiro Haga, Ph.D., Jun Itami, M.D., Ph.D., Keiichi Nakagawa, M.D., Ph.D.

Malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) are the most common types of malignant brain tumors in adults, and are generally treated by maximal resection followed by concurrent chemoradiotherapy with temozolomide and 60 Gy of radiotherapy. The treatment results of malignant gliomas are poor because the tumors recur from the initial tumor sites in a majority of the patients. Thus researchers have tried to deliver higher doses to the primary tumor, but in spite of such efforts at dose escalation, most of the trials have resulted in no apparent benefit.


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