Articles in Press
Volume 4 Issue 1
A Case of HPV-positive Oropharyngeal Cancer with Second Primary Tumor –Implications for Treatment and Follow-up
Brian S. Bingham BS*, James Lewis MD, Anthony J. Cmelak MD
Over the past 15 years, human papillomavirus (HPV) has become a well-known etiologic factor in the development of squamous cell carcinoma of the head and neck, particularly of the oropharynx. Although current guidelines do not identify HPV-positivity as a factor to consider in determining treatment deintensification, recognition of HPV-positive squamous cell carcinomas as a distinct clinical entity with less risk for second primary tumors raises the question of the appropriateness of ipsilateral definitive surgery or radiotherapy in HPV-positive patients.